The entourage effect is a key concept in the therapeutic use of cannabis. It refers to the complex interplay between different compounds found in the cannabis plant, such as cannabinoids, terpenes and flavonoids, which act synergistically to maximize therapeutic benefits.


Cannabinoids, such as CBG, CBN and CBD, are the main active compounds in cannabis. They interact with receptors in the body's endocannabinoid system, thereby regulating various physiological processes.

When used together, cannabinoids can produce complementary effects.


Terpenes are the aromatic compounds found in cannabis, which give each strain its distinctive flavor and scent.

Besides their role in creating aromas, terpenes also have therapeutic properties. For example, limonene is known for its anxiolytic effects, alpha-pinene for its anti-inflammatory properties, and linalool for its relaxing properties.

When combined with cannabinoids, terpenes can alter the pharmacological effects of cannabis, contributing to the entourage effect. This synergy allows to improve the therapeutic properties and to personalize the effects of cannabis according to the needs of each individual.


Flavonoids are phytochemicals found in many plants, including cannabis. They are known for their antioxidant, anti-inflammatory and neuroprotective properties.

Although cannabis flavonoids have been less studied than cannabinoids and terpenes, preliminary research suggests that they may also contribute to the entourage effect by enhancing the beneficial effects of other cannabis compounds.

In sum, the entourage effect in cannabis offers a holistic and synergistic approach to maximizing therapeutic benefits. By understanding and harnessing this complex interplay between cannabis compounds, it is possible to optimize the medicinal use of this plant and improve the quality of life for people suffering from various conditions.